abstract：AIMS:The totally subcutaneous implantable-defibrillator (S-ICD) is a new alternative to the conventional transvenous ICD system to minimize intravascular lead complications. There are limited data describing the long-term performance of the S-ICD. This paper presents the first large international patient population col...

journal_title：European heart journal

authors： Lambiase PD,Barr C,Theuns DA,Knops R,Neuzil P,Johansen JB,Hood M,Pedersen S,Kääb S,Murgatroyd F,Reeve HL,Carter N,Boersma L,EFFORTLESS Investigators.

更新日期：2014-07-01 00:00:00

abstract：AIMS:Older people increasingly constitute a large proportion of the acute coronary syndrome (ACS) population. We examined the relationship of age with receipt of more intensive management and secondary prevention medicine. Then, the comparative association of intensive management (reperfusion/angiography) over a conser...

journal_title：European heart journal

authors： Zaman MJ,Stirling S,Shepstone L,Ryding A,Flather M,Bachmann M,Myint PK

更新日期：2014-06-14 00:00:00

abstract：AIM:Short-term psychological stress is associated with an immediate physiological response and may be associated with a transiently higher risk of cardiovascular events. The aim of this study was to determine whether brief episodes of anger trigger the onset of acute myocardial infarction (MI), acute coronary syndromes...

journal_title：European heart journal

authors： Mostofsky E,Penner EA,Mittleman MA

更新日期：2014-06-01 00:00:00

abstract：AIMS:Using a large, contemporary primary care population we aimed to provide absolute long-term risks of cardiovascular death (CVD) based on the QTc interval and to test whether the QTc interval is of value in risk prediction of CVD on an individual level. METHODS AND RESULTS:Digital electrocardiograms from 173 529 pr...

journal_title：European heart journal

authors： Nielsen JB,Graff C,Rasmussen PV,Pietersen A,Lind B,Olesen MS,Struijk JJ,Haunsø S,Svendsen JH,Køber L,Gerds TA,Holst AG

更新日期：2014-05-21 00:00:00

abstract：:There is no certain way of obtaining one of the European Society of Cardiology grants for research or clinical training offered each year, but Prof. Stavros Konstantinides (Centre for Thrombosis and Haemostasis, Johannes Gutenberg University, Mainz, Germany), who chairs the European Society of Cardiology Credentials C...

journal_title：European heart journal

authors：

更新日期：2014-05-14 00:00:00

abstract：:Stress echocardiography is an established method for the diagnosis and prognostic stratification of coronary artery disease. In the last few years, the tremendous technological and conceptual versatility of this technique has been increasingly applied in challenging diagnostic fields. Today, in the echocardiography la...

journal_title：European heart journal

authors： Picano E,Pellikka PA

更新日期：2014-04-01 00:00:00

abstract：AIMS:The aim of this study was to investigate the effect of Arginase I (ArgI) on plaque stabilization in unruptured atherosclerotic plaque and explore its mechanism. METHODS AND RESULTS:The atherosclerotic plaque model was established in New Zealand rabbits by balloon injury of abdominal arteries and a high cholestero...

journal_title：European heart journal

authors： Wang XP,Zhang W,Liu XQ,Wang WK,Yan F,Dong WQ,Zhang Y,Zhang MX

更新日期：2014-04-01 00:00:00

abstract：AIMS:The population with stable coronary artery disease (SCAD) is growing but validated models to guide their clinical management are lacking. We developed and validated prognostic models for all-cause mortality and non-fatal myocardial infarction (MI) or coronary death in SCAD. METHODS AND RESULTS:Models were develop...

journal_title：European heart journal

authors： Rapsomaniki E,Shah A,Perel P,Denaxas S,George J,Nicholas O,Udumyan R,Feder GS,Hingorani AD,Timmis A,Smeeth L,Hemingway H

更新日期：2014-04-01 00:00:00

abstract：AIMS:Hitherto, sudden cardiac death in children (SCDc)-defined as sudden cardiac death (SCD) in the 1-18 years old-has been incompletely described in the general population. Knowledge on incidence rates, causes of death and symptoms prior to death is sparse and has been affected by reporting and referral bias. METHODS...

journal_title：European heart journal

authors： Winkel BG,Risgaard B,Sadjadieh G,Bundgaard H,Haunsø S,Tfelt-Hansen J

更新日期：2014-04-01 00:00:00

abstract：:Large-scale randomized clinical trials have established the efficacy of cholesterol-lowering, blood pressure-lowering, and anti-platelet therapy to prevent cardiovascular diseases. A challenge for clinicians is to apply group-level evidence from these trials to individual patients. Trials typically report a single tre...

journal_title：European heart journal

authors： van der Leeuw J,Ridker PM,van der Graaf Y,Visseren FL

更新日期：2014-04-01 00:00:00

abstract：:The Alliance for Biomedical Research in Europe, co-founded by the European Society of Cardiology, has persuaded the European Parliament to move towards European Union-wide means of better directing and coordinating biomedical research, from the laboratory bench to the marketplace. ...

journal_title：European heart journal

authors： Shurlock B

更新日期：2014-04-01 00:00:00

abstract：AIMS:Diastolic dysfunction in acute myocardial infarction (MI) is associated with adverse outcome. Recently, the ratio of early mitral inflow velocity (E) to global diastolic strain rate (e'sr) has been proposed as a marker of elevated LV filling pressure. However, the prognostic value of this measure has not been demo...

journal_title：European heart journal

authors： Ersbøll M,Andersen MJ,Valeur N,Mogensen UM,Fakhri Y,Thune JJ,Møller JE,Hassager C,Søgaard P,Køber L

更新日期：2014-03-01 00:00:00

abstract：AIMS:We evaluated the feasibility and the acute performance of the everolimus-eluting bioresorbable vascular scaffolds (BVS) for the treatment of patients presenting with ST-segment elevation myocardial infarction (STEMI). METHODS AND RESULTS:The present investigation is a prospective, single-arm, single-centre study,...

journal_title：European heart journal

authors： Diletti R,Karanasos A,Muramatsu T,Nakatani S,Van Mieghem NM,Onuma Y,Nauta ST,Ishibashi Y,Lenzen MJ,Ligthart J,Schultz C,Regar E,de Jaegere PP,Serruys PW,Zijlstra F,van Geuns RJ

更新日期：2014-03-01 00:00:00

abstract：:The natriuretic peptides (NPs) family, including atrial, B-type, and C-type NPs, is a group of hormones possessing relevant haemodynamic and anti-remodelling actions in the cardiovascular (CV) system. Due to their diuretic, natriuretic, vasorelaxant, anti-proliferative, and anti-hypertrophic effects, they are involved...

journal_title：European heart journal

authors： Volpe M,Rubattu S,Burnett J Jr

更新日期：2014-02-01 00:00:00

abstract：AIMS:We investigated the potential influence of a moderate-to-high cardiovascular (CV) risk (CVR) (defined as a Systematic COronary Risk Evaluation model, or SCORE ≥ 4%), in the absence of an established CV disease, on the duration and cost of CV and non-CV sick leave (SL) resulting from common and occupational acciden...

journal_title：European heart journal

authors： Calvo-Bonacho E,Ruilope LM,Sánchez-Chaparro MA,Cerezo C,Catalina-Romero C,Martínez-Muñoz P,Banegas JR,Waeber B,Gonzalez-Quintela A,Zanchetti A

更新日期：2014-02-01 00:00:00

abstract：AIMS:The purpose of this study was to identify novel genetic variants influencing circulating asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) levels and to evaluate whether they have a prognostic value on cardiovascular mortality. METHODS AND RESULTS:We conducted a genome-wide association stud...

journal_title：European heart journal

authors： Seppälä I,Kleber ME,Lyytikäinen LP,Hernesniemi JA,Mäkelä KM,Oksala N,Laaksonen R,Pilz S,Tomaschitz A,Silbernagel G,Boehm BO,Grammer TB,Koskinen T,Juonala M,Hutri-Kähönen N,Alfthan G,Viikari JS,Kähonen M,Raitakari OT,

更新日期：2014-02-01 00:00:00

abstract：AIMS:Monocytes are critical mediators of healing following acute myocardial infarction (AMI), making them an interesting target to improve myocardial repair. The purpose of this study was a gain of insight into the source and recruitment of monocytes following AMI in humans. METHODS AND RESULTS:Post-mortem tissue spec...

journal_title：European heart journal

authors： van der Laan AM,Ter Horst EN,Delewi R,Begieneman MP,Krijnen PA,Hirsch A,Lavaei M,Nahrendorf M,Horrevoets AJ,Niessen HW,Piek JJ

更新日期：2014-02-01 00:00:00

abstract：AIMS:We investigated the temporal changes in circulating levels of markers of extracellular cardiac matrix (ECCM) turnover and their relationship with infarct size (IS), ejection fraction (EF), and left ventricular (LV) volumes, determined by serial cardiac magnetic resonance (CMR) imaging in patients with first-time S...

journal_title：European heart journal

authors： Manhenke C,Ueland T,Jugdutt BI,Godang K,Aukrust P,Dickstein K,Ørn S

更新日期：2014-02-01 00:00:00

abstract：:The natriuretic peptides are important tools to establish diagnosis and prognosis in heart failure (HF). With application of therapies for HF, changes in both B-type natriuretic peptide (BNP) and its amino terminal cleavage fragment (NT-proBNP) parallel the benefits of the HF therapy applied. This dynamic nature of BN...

journal_title：European heart journal

authors： Troughton R,Michael Felker G,Januzzi JL Jr

更新日期：2014-01-01 00:00:00

abstract：AIMS:We investigated the prevalence of prior myocardial infarction (MI) and incidence of ischaemic cardiovascular (CV) events among atrial fibrillation (AF) patients. METHODS AND RESULTS:In ROCKET AF, 14 264 patients with nonvalvular AF were randomized to rivaroxaban or warfarin. The key efficacy outcome for these ana...

journal_title：European heart journal

authors： Mahaffey KW,Stevens SR,White HD,Nessel CC,Goodman SG,Piccini JP,Patel MR,Becker RC,Halperin JL,Hacke W,Singer DE,Hankey GJ,Califf RM,Fox KA,Breithardt G,ROCKET AF Investigators.

更新日期：2014-01-01 00:00:00

abstract：AIMS:Characteristics of sudden cardiac arrest (SCA) during sports offers a novel (and unexplored) setting to assess factors associated with disparities in outcomes across regions. METHODS AND RESULTS:From a prospective 5-year community-based French registry concerning SCA during sports in 10-75 year-olds, we evaluated...

journal_title：European heart journal

authors： Marijon E,Bougouin W,Celermajer DS,Perier MC,Benameur N,Lamhaut L,Karam N,Dumas F,Tafflet M,Prugger C,Mustafic H,Rifler JP,Desnos M,Le Heuzey JY,Spaulding CM,Avillach P,Cariou A,Empana JP,Jouven X

更新日期：2013-12-01 00:00:00

abstract：AIMS:Although regular physical activity has beneficial cardiovascular effects, exercise can trigger an acute cardiac event. We aimed to determine the incidence and prognosis of exercise-related out-of-hospital cardiac arrest (OHCA) in the general population. METHODS AND RESULTS:We prospectively collected all OHCAs in ...

journal_title：European heart journal

authors： Berdowski J,de Beus MF,Blom M,Bardai A,Bots ML,Doevendans PA,Grobbee DE,Tan HL,Tijssen JG,Koster RW,Mosterd A

更新日期：2013-12-01 00:00:00

abstract：AIMS:Aldosterone plays a crucial role in cardiovascular disease. 'Systemic' inhibition of its mineralocorticoid receptor (MR) decreases atherosclerosis by reducing inflammation and oxidative stress. Obesity, an important cardiovascular risk factor, is an inflammatory disease associated with increased plasma aldosterone...

journal_title：European heart journal

authors： Schäfer N,Lohmann C,Winnik S,van Tits LJ,Miranda MX,Vergopoulos A,Ruschitzka F,Nussberger J,Berger S,Lüscher TF,Verrey F,Matter CM

更新日期：2013-12-01 00:00:00

abstract：:Recently published epidemiological and genetic studies strongly suggest a causal relationship of elevated concentrations of lipoprotein (a) [Lp(a)] with cardiovascular disease (CVD), independent of low-density lipoproteins (LDLs), reduced high density lipoproteins (HDL), and other traditional CVD risk factors. The ath...

journal_title：European heart journal

authors： Kostner KM,März W,Kostner GM

更新日期：2013-11-01 00:00:00

abstract：AIMS:Despite the known benefits of regular exercise, the reasons why many coronary heart disease (CHD) patients engage in little physical activity are not well understood. This study identifies factors associated with low activity levels in individuals with chronic CHD participating in the STABILITY study, a global cli...

journal_title：European heart journal

authors： Stewart R,Held C,Brown R,Vedin O,Hagstrom E,Lonn E,Armstrong P,Granger CB,Hochman J,Davies R,Soffer J,Wallentin L,White H

更新日期：2013-11-01 00:00:00

abstract：AIMS:Reperfusion injury following acute myocardial infarction impacts not only on the myocardium but also on the coronary microcirculation, and microembolization from the culprit lesion contributes to microvascular obstruction. Prior experimental studies have not accounted for microembolization in ischaemia/reperfusion...

journal_title：European heart journal

authors： Skyschally A,Walter B,Heusch G

更新日期：2013-11-01 00:00:00

abstract：:This overview provides a Europe-wide update on the current burden of cardiovascular disease, and specifically of coronary heart disease and stroke. Cardiovascular disease continues to cause a large proportion of deaths and disability in Europe, and places a substantial burden on the health care systems and economies o...

journal_title：European heart journal

authors： Nichols M,Townsend N,Scarborough P,Rayner M

更新日期：2013-10-01 00:00:00

abstract：:Pulmonary disease is common in patients with heart failure, through shared risk factors and pathophysiological mechanisms. Adverse pulmonary vascular remodelling and chronic systemic inflammation characterize both diseases. Concurrent chronic obstructive pulmonary disease presents diagnostic and therapeutic challenges...

journal_title：European heart journal

authors： Hawkins NM,Virani S,Ceconi C

更新日期：2013-09-01 00:00:00

abstract：AIMS:Our objective was to create a simple prognostic risk score for patients with systolic heart failure and mild symptoms. We then assessed the efficacy of eplerenone across different categories of risk. METHODS AND RESULTS:The Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure trial (EMP...

journal_title：European heart journal

authors： Collier TJ,Pocock SJ,McMurray JJ,Zannad F,Krum H,van Veldhuisen DJ,Swedberg K,Shi H,Vincent J,Pitt B

更新日期：2013-09-01 00:00:00

abstract：AIMS:Induced pluripotent stem cells (iPSCs) provide a unique opportunity for the generation of patient-specific cells for use in disease modelling, drug screening, and regenerative medicine. The aim of this study was to compare human-induced pluripotent stem cells (hiPSCs) derived from different somatic cell sources re...

journal_title：European heart journal

authors： Streckfuss-Bömeke K,Wolf F,Azizian A,Stauske M,Tiburcy M,Wagner S,Hübscher D,Dressel R,Chen S,Jende J,Wulf G,Lorenz V,Schön MP,Maier LS,Zimmermann WH,Hasenfuss G,Guan K

更新日期：2013-09-01 00:00:00

abstract：AIMS:Despite disparities in pathophysiology and disease manifestation between male and female patients with heart failure, studies focusing on sex differences in biomarkers are scarce. The purpose of this study was to assess sex-specific variation in clinical characteristics and biomarker levels to gain more understand...

journal_title：European heart journal

authors： Meyer S,van der Meer P,van Deursen VM,Jaarsma T,van Veldhuisen DJ,van der Wal MH,Hillege HL,Voors AA

更新日期：2013-08-01 00:00:00

abstract：AIMS:To determine the relation between serum concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) and prognosis in patients with hypertrophic cardiomyopathy (HCM). METHODS AND RESULTS:In total, 847 patients (53 ± 15 years; 67% male) with HCM (28% with left ventricular outflow tract obstruction ≥ 30 m...

journal_title：European heart journal

authors： Coats CJ,Gallagher MJ,Foley M,O'Mahony C,Critoph C,Gimeno J,Dawnay A,McKenna WJ,Elliott PM

更新日期：2013-08-01 00:00:00

abstract：AIMS:The combined use of cardiac computed tomography (CT) coronary angiography (CTCA) and myocardial perfusion imaging allows the non-invasive evaluation of coronary morphology and function. Cardiovascular magnetic resonance (CMR) imaging has several advantages: it can simultaneously assess myocardial perfusion, ventri...

journal_title：European heart journal

authors： Groothuis JG,Beek AM,Brinckman SL,Meijerink MR,van den Oever ML,Hofman MB,van Kuijk C,van Rossum AC

更新日期：2013-07-01 00:00:00

abstract：AIMS:The cardiac extracellular matrix is highly involved in regulating inflammation, remodelling, and function of the heart. Whether matrix alterations relate to the degree of inflammation, fibrosis, and overall rejection in the human transplanted heart remained, until now, unknown. METHODS AND RESULTS:Expression of m...

journal_title：European heart journal

authors： Vanhoutte D,van Almen GC,Van Aelst LN,Van Cleemput J,Droogné W,Jin Y,Van de Werf F,Carmeliet P,Vanhaecke J,Papageorgiou AP,Heymans S

更新日期：2013-07-01 00:00:00

abstract：:Patients who have experienced a myocardial infarction (MI) are at increased risk of sudden cardiac death (SCD). With the advent of implantable cardioverter-defibrillators (ICDs), accurate risk stratification has become very relevant. Numerous investigations have proven that a reduced left ventricular ejection fraction...

journal_title：European heart journal

authors： Dagres N,Hindricks G

更新日期：2013-07-01 00:00:00

abstract：AIMS:There is currently no medical therapy that can prevent the progression of aortic valve stenosis (AS). Recent data highlight a possible relationship between bone metabolism and AS progression but prospective data are lacking. METHODS AND RESULTS:Serum levels of calcium, phosphorus, creatinine, 25-OH vitamin D, int...

journal_title：European heart journal

authors： Hekimian G,Boutten A,Flamant M,Duval X,Dehoux M,Benessiano J,Huart V,Dupré T,Berjeb N,Tubach F,Iung B,Vahanian A,Messika-Zeitoun D

更新日期：2013-07-01 00:00:00

abstract：AIMS:Emerging evidence indicates that nuclear receptors play a critical regulatory role in cardiovascular physiology/pathology. Recently, farnesoid-X-receptor (FXR), a member of the metabolic nuclear receptor superfamily, has been demonstrated to be expressed in vascular cells, with important roles in vascular physiolo...

journal_title：European heart journal

authors： Pu J,Yuan A,Shan P,Gao E,Wang X,Wang Y,Lau WB,Koch W,Ma XL,He B

更新日期：2013-06-01 00:00:00

abstract：:Coronary heart disease (CHD) is the leading cause of death and disability in Europe. For patients presenting with an acute ST-segment elevation myocardial infarction (STEMI), timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous coronary intervention (PPCI) is the most effective thera...

journal_title：European heart journal

authors： Fröhlich GM,Meier P,White SK,Yellon DM,Hausenloy DJ

更新日期：2013-06-01 00:00:00

abstract：:Oxygen supplementation is a standard treatment for all patients who present with acute coronary syndrome, regardless of oxygen saturation levels. Most of the data regarding the function of oxygen in myocardial infarction is based on a limited number of basic and clinical studies. We performed a systematic literature r...

journal_title：European heart journal

authors： Shuvy M,Atar D,Gabriel Steg P,Halvorsen S,Jolly S,Yusuf S,Lotan C

更新日期：2013-06-01 00:00:00

abstract：AIMS:Pericardial effusion (PE) is a common finding in cardiac patients with chronic heart failure. The prognostic relevance of a small, haemodynamically non-compromising PE in such patients, however, remains to be determined. METHODS AND RESULTS:All patients referred to our heart failure clinic and having a baseline e...

journal_title：European heart journal

authors： Fröhlich GM,Keller P,Schmid F,Wolfrum M,Osranek M,Falk C,Noll G,Enseleit F,Reinthaler M,Meier P,Lüscher TF,Ruschitzka F,Tanner FC

更新日期：2013-05-01 00:00:00